Associate Professor of Bioinformatics
Dr. Georges Khazen is an associate professor of bioinformatics. He has a multidisciplinary background with strong analytical and statistical skills. Dr. Khazen joined LAU in 2011 as an assistant professor of bioinformatics.
Dr. Khazen’s current research focuses on reverse engineering the distribution of different neuron types in the neocortex as well as the analysis of population stratification in the Levant population.
Dr. Khazen studied Biology at the Lebanese University and went on to study Computer Engineering at the American University of Beirut, Lebanon. He received his MA in Bioinformatics from the University of Oxford, United Kingdom, where he was awarded a dissertation distinction award from Lincoln College for his work on gene regulatory networks and the application of Logic Gate techniques for the analysis of gene expression data. He pursued his PhD in Computational Neuroscience at the Ecole Polytechnique Fédérale de Lausanne, and received the Dean’s Award for outstanding achievement for his work at the Blue Brain Project.
His thesis focused on building a generic predictive model to reverse engineer the membrane composition of neocortical neurons. This involved the exploitation of online resources to provide information on the molecular, physiological and structural properties of transmembrane proteins present in neurons as well as their levels of expression and sub-cellular localization. The data collected in this way was integrated in a system of linear equations and used to compute an upper bound on how much of each protein is present in any given neuron.
Milane A, Khazen G, Zeineddine N, Amro M, Masri L, Ghassibe-Sabbagh M, Youhannaa S, Salloum A, Haber M, Platt DE, Cazier J-B, Othman R, Kabbani S, Sbeite H, Chamia Y, Chammas E, El Bayeh H, Gauguier D, Abchee A, Zalloua P, Barbari A. “Association of coronary artery disease and chronic kidney disease in Lebanese population.” Int. J of Clinical and Experimental Medicine. In Press 2015
Doumit R, Zeeni N, Sanchez Ruiz MJ, Khazen G. Anxiety as a Moderator of the Relationship Between Body Image and Restrained Eating. Perspect Psychiatr Care. 2015 Jun 1. doi: 10.1111/ppc.12126.
Syed ZA, Moayedi J, Mohamedi M, Tashter J, Anthony T, Celiker C, Khazen G, Melki SA. Cataract surgery outcomes at a UK independent sector treatment centre. Br J Ophthalmol. 2015 Apr 29. pii: bjophthalmol-2014-306586. doi: 10.1136/bjophthalmol-2014-306586.
Merhi M, Demirdjian S, Hariri E, Sabbah N, Youhanna S, Ghassibe-Sabbagh M, Naoum J, Haber M, Othman R, Kibbani S, Chammas E, Kanbar R, Bayeh HE, Chami Y, Abchee A, Platt DE, Zalloua P, Khazen G. Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk. Inflamm Res. 2015 Jun;64(6):415-22. doi: 10.1007/s00011-015-0821-1. Epub 2015 Apr 24.
Doumit R, Khazen G, Katsounari I, Kazandjian C, Long J, Zeeni N. Investigating Vulnerability for Developing Eating Disorders in a Multi-confessional Population. Community Ment Health J. 2015 Mar 31.
Milane A, Abdallah J, Kanbar R, Khazen G, Ghassibe-Sabbagh M, Salloum AK, Youhanna S, Saad A, El Bayeh H, Chammas E, Platt DE, Hager J, Gauguier D, Zalloua P, Abchee A; FGENTCARD Consortium. Association of hypertension with coronary artery disease onset in the Lebanese population. Springerplus. 2014 Sep 16;3:533. doi: 10.1186/2193-1801-3-533. eCollection 2014.
Platt DE, Ghassibe-Sabbagh M, Youhanna S, Hager J, Cazier JB, Kamatani Y, Salloum AK, Haber M, Romanos J, Doueihy B, Mouzaya F, Kibbani S, Sbeite H, Deeb ME, Chammas E, El Bayeh H, Khazen G, Gauguier D, Zalloua PA, Abchee AB; FGENTCARD Consortium. Circulating lipid levels and risk of coronary artery disease in a large group of patients undergoing coronary angiography. J Thromb Thrombolysis. 2015 Jan;39(1):15-22. doi: 10.1007/s11239-014-1069-2.
Favre MR, Barkat TR, LaMendola D, Khazen G, Markram H and Markram K (2013) General developmental health in the VPA-rat model of autism. Front. Behav. Neurosci.7:88. doi: 10.3389/fnbeh.2013.00088
Badro DA, Douaihy B, Haber M, Youhanna SC, Salloum A, Ghassibe-Sabbagh M, Johnsrud B, Khazen G, Matisoo-Smith E, Soria-Hernanz DF, Wells RS, Tyler-Smith C, Platt DE, Zalloua PA; Genographic Consortium (2013) Y-Chromosome and mtDNA Genetics Reveal Significant Contrasts in Affinities of Modern Middle Eastern Populations with European and African Populations. PLoS ONE 8(1): e54616. doi:10.1371/journal.pone.0054616
Khazen G, Ghobril JP, Meystre J, Muller E, Telefont M, Schuermann Fand Markram H (2012). “A unifying model of the neocortical column 8: Distribution of Cell Types”.Society for Neuroscience, New Orleans 2012, USA
Jörg Hager, Yoichiro Kamatani, Jean-Baptiste Cazier, Sonia Youhanna,Michella Ghassibe-Sabbagh, Daniel E. Platt, Antoine B. Abchee, Jihane Romanos, Georges Khazen, Raed Othman, Danielle A. Badro, Marc Haber, Angelique K. Salloum, Bouchra Douaihy, Nabil Shasha, Samer Kibbani, Hana Sbeite, Elie Chammas, Hamid el Bayeh, Francis Rousseau, Diana Zelenika, Ivo Gut, Mark Lathrop, Martin Farrall, Dominique Gauguier, Pierre A. Zalloua, and the FGENTCARD Consortium (2012). “Genome-wide Association Study in a Lebanese Cohort Confirms PHACTR1 as a Major Determinant of Coronary Artery Stenosis”. PLoS ONE 7(6): e3866. doi: 10.1371/journal.pone.0038663
Khazen G, Hill S, Schürmann F and Markram H (2012). “Combinatorial Expression Rules of Ion Channel Genes in Juvenile Rat Neocortical Neurons”. PLoS ONE7(4):e34786. do i:10.1371/journal.pone.0034786
Ranjan R, Khazen G, Gambazzi L and Markram H (2011). “ChannelPedia: An integrative and interactive database for ion channels.” Front. Neuroinform. 5:36. doi: 10.3389/fninf.2011.00036
Stephanie Saade, Jean-Baptiste Cazier, Michella Ghassibe-Sabbagh, Sonia Youhanna, Danielle A. Badro, Yoichiro Kamatani, Jörg Hager, Joumana S. Yeretzian, Georges Khazen, Marc Haber, Angelique K. Salloum, Bouchra Douaihy, Raed Othman, Nabil Shasha, Samer Kabbani, Hamid El Bayeh, Elie Chammas, Martin Farrall, Dominique Gauguier, Daniel E. Platt, Pierre A. Zalloua and the FGENTCARD consortium (2011). “Large Scale Association Analysis Identifies Three Susceptibility Loci for Coronary Artery Disease”. PLoS ONE 6(12): e29427. doi:10.1371/journal.pone.0029427
Khazen G, Hill S, Schürmann F and Markram H (2010). “iSVM: an incremental machine learning approach for recreating ion channel profiles in neocortical neurons.” Frontiers in Neuroscience. Conference Abstract: Neuroinformatics, Kobe, 2010. doi: 10.3389/conf.fnins.2010.13.00051
Alwan A, Youhanna S, Platt D, El-Sibai M, Deeb M, Khazen G, Saade S, Zreik T, El Bayeh H, Maalouf A, Abchee A and Zalloua P. (2010) “ALOX5AP Gene Variants Show Differential Association with Coronary Artery Disease In Different Populations.” 2010, vol. 1, no3, pp. 107-115 Journal of Community Genetics
Mahfouz RA, Sabbagh AS, Shamseddine W, Bazarbachi A, Ibrahim G, Arayssi T, El Hajj N, Rayes R, Zaatari GS, Khazen G and Khalaf RA (2009) “Distribution of killer cell immunoglobulin-like receptor (KIR) genotypes in patients with familial Mediterranean fever.” Genet Test Mol Biomarkers. 2009 Feb;13(1):91-5.
Rayes R, Bazarbachi A, Khazen G, Sabbagh AS, Zaatari GS and Mahfouz RA (2007) “Natural Killer Cell Immunoglobulin-like Receptors (KIR) Genotypes in two Arab Populations: Will KIR become a genetic landmark between nations?” Mol Biol Rep. 03/2007
- PhD in Neuroscience, Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland, 2011
- MSc in Bioinformatics, University of Oxford, United Kingdom
- BE in Computer and Communication Engineering, AUB
- Certificate in Biology, Lebanese University