About

Philippe Hussein Kobeissy

Assistant Professor of Biology

Dr. Philippe Hussein Kobeissy joined LAU in 2022 as a full-time assistant professor of cell biology at the Department of Natural Sciences. He received his BS in Biochemistry from the Lebanese University in 2013 and his MS in Cell Biology, Microbiology and Therapeutic Innovation from Paris-Saclay Université in France. He moved on to pursue his PhD at the same university, where his thesis focused on host-pathogen interaction and the regulation of intestinal inflammation associated with inflammatory bowel diseases and clostridium difficile infection.

Research Interests

His work led to accepted patents and the start of an early drug development program of an anti-inflammatory microRNA. In 2019, he joined the Department of Medicine at Columbia University in New York, US where he worked on functional genomics of Idiopathic Pulmonary Fibrosis as well as the regulation of Colorectal Cancer-associated hypoxia signaling pathway. 

SDGs Research Mapping

Dr. Philippe Hussein Kobeissy conducts research relevant to the following SDGs:

Selected Publications

  • David Zhang, Philippe H. Kobeissy, Gundula Povysil, Qi Li, Binhan Wang, Mason Amelotte, Hajer Jaouadi, Chad A. Newton, Toby M. Maher, Philip L. Molyneaux, Imre Noth, Scott Palmer, Carolina Haefliger, Adam Platt, Slavé Petrovski, Joseph A. Garcia, David B. Goldstein, Christine Kim Garcia. “Rare and Common Variants in KIF15 Contribute to Genetic Risk of Idiopathic Pulmonary Fibrosis,” 2022. AJRCCM 206(1):56-69.
  • Jason S. Nagati*, Philippe H. Kobeissy*, Minh Q. Nguyen, Min Xu, Trent Garcia, Sarah A. Comerford, Robert E. Hammer, Joseph A. Garcia. “Mammalian acetate-dependent acetyl CoA synthetase 2 contains multiple protein destabilization and masking elements,” 2021. J Biol Chem 297(3):101037. (*Joint first authorship) 
  • Mesquita T., Auguste G., Falcón D., Ruiz-Hurtado G., Salazar-Enciso R., Sabourin J., Lefebvre F., Viengchareun S., Kobeissy H., Lechêne P., Nicolas V., Fernández-Celis A., Gomez S., Lauton-Santos S., Morel E., Rueda A., López-Andrés N., Gomez A., Lombes M., Benitah J. “Specific Activation of the Alternative Cardiac Promoter of Cacna1c by the Mineralocorticoid Receptor,” 2018. Circulation Research 117.312451
  • Batah J.*, Kobeissy H.*, Bui Pham PT., Denève-Larrazet C., Kuehne S., Collignon A., Janoir-Jouveshomme C., Marvaud JC. And Kansau I. “Clostridium difficile flagella induce a pro-inflammatory response in intestinal epithelium of mice in cooperation with toxins,” 2017. Scientific Reports 7(1):3256 (*Joint first authorship).

Academic Degrees

  • PhD in Cell Biology, Microbiology and Therapeutic Innovation, University of Paris-Saclay, 2018.
  • MS in Cell Biology, Microbiology, University of Paris-Saclay, 2015.
  • BS in Biochemistry, Lebanese University, 2013.

Patents

Philippe Hussein Kobeissy, Cécile Denève-Larrazet, Jean-Christophe Marvaud and Imad Kansau. “Use of the miR-27a-5p microRNA for treating Clostridium difficile-induced bowel inflammation.” 2021. PCT WO2020/094865 A1.